Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:28854
Term: 2,4-D
Definition: A chlorophenoxyacetic acid that is phenoxyacetic acid in which the ring hydrogens at postions 2 and 4 are substituted by chlorines.
Chemical ID: MESH:D015084
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases expressionEXP 6480464CTD2,4-Dichlorophenoxyacetic Acid results in increased expression of CASP3 protein; 2,4-Dichlorophenoxyacetic Acid results in increased expression of CASP3 protein modified formPMID:36214342
Casp3multiple interactionsEXP 6480464CTD[2,4-dichlorophenoxyacetic acid isooctyl ester results in increased abundance of 2,4-Dichlorophenoxyacetic Acid] promotes the reaction [Ethanol results in increased expression of CASP3 mRNA]; [2,4-dichlorophenoxyacetic acid isooctyl ester results in increased abundance of 2,4-Dichlorophenoxyacetic Acid] which results in increased expression of CASP3 mRNA; Ethanol promotes the reaction [[2,4-dichlorophenoxyacetic acid isooctyl ester results in increased abundance of 2,4-Dichlorophenoxyacetic Acid] which results in increased expression of CASP3 mRNA]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of CASP3 protein modified form]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of CASP3 protein]PMID:36085217 PMID:36214342
Casp3increases expressionISOCasp3 (Mus musculus)6480464CTD2,4-Dichlorophenoxyacetic Acid results in increased expression of CASP3 protein; 2,4-Dichlorophenoxyacetic Acid results in increased expression of CASP3 protein modified formPMID:36214342
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTD2,4-Dichlorophenoxyacetic Acid inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in increased expression of CASP3 mRNA]; FAS protein promotes the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of CASP3 protein modified form]; FAS protein promotes the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of CASP3 protein]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of CASP3 protein modified form]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of CASP3 protein]PMID:36214342 PMID:37516258
Go Back to source page   Continue to Ontology report