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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:16836
Term: 4-nitrophenol
Definition: A member of the class of 4-nitrophenols that is phenol in which the hydrogen that is para to the hydroxy group has been replaced by a nitro group.
Chemical ID: MESH:C024836
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3decreases expressionISOCasp3 (Mus musculus)6480464CTD4-nitrophenol results in decreased expression of CASP3 mRNAPMID:34673133
Casp3increases activityISOCasp3 (Mus musculus)6480464CTD4-nitrophenol results in increased activity of CASP3 proteinPMID:23997041
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTDQuercetin inhibits the reaction [4-nitrophenol results in increased activity of CASP3 protein]PMID:23997041
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