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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2252
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ddr1
Name: discoidin domain receptor tyrosine kinase 1
Acc ID: CHEBI:191410
Term: DDR1-IN-2
Definition: A secondary carboxamide resulting from the formal condensation of the carboxy group of 4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzoic acid with the primary amino group of N(3)-[(4-methoxy-1H-pyrrolo[2,3-b]pyridin-5-yl)methyl]-4-methylbenzene-1,3-diamine. It is a potent inhibitor of discoidin domain receptor tyrosine kinase 1 and 2 (DDR1/2) with IC50 = 47 nM and 145 nM, respectively.
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ddr1multiple interactionsISODDR1 (Homo sapiens)152995467RGDDDR1-IN-2 inhibits the reaction [collagen increases DDR1 autophosphorylation in human cell lines] 
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