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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2247
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cacna2d1
Name: calcium voltage-gated channel auxiliary subunit alpha2delta 1
Acc ID: CHEBI:64356
Term: pregabalin
Definition: A gamma-amino acid that is gamma-aminobutyric acid (GABA) carrying an isobutyl substitutent at the beta-position (the S-enantiomer). Binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues.
Chemical ID: MESH:D000069583
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cacna2d1affects localizationEXP 6480464CTDPregabalin affects the localization of CACNA2D1 proteinPMID:22949532
Cacna2d1decreases expressionEXP 6480464CTDPregabalin results in decreased expression of CACNA2D1 mRNAPMID:19339603
Cacna2d1multiple interactionsEXP 6480464CTDPregabalin binds to and affects the activity of CACNA2D1 protein; Pregabalin results in decreased expression of and affects the localization of CACNA2D1 proteinPMID:19339603 PMID:22949532
Cacna2d1affects bindingISOCacna2d1 (Mus musculus)6480464CTDPregabalin binds to CACNA2D1 proteinPMID:16460711
Cacna2d1affects response to substanceISOCacna2d1 (Mus musculus)6480464CTDCACNA2D1 affects the susceptibility to PregabalinPMID:24269977
Cacna2d1decreases response to substanceISOCacna2d1 (Mus musculus)6480464CTDCACNA2D1 gene mutant form results in decreased susceptibility to PregabalinPMID:24133248
Cacna2d1multiple interactionsISOCacna2d1 (Mus musculus)6480464CTDCACNA2D1 protein affects the susceptibility to and affects the activity of Pregabalin; Pregabalin binds to and affects the activity of CACNA2D1 proteinPMID:17088553 PMID:24269977
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