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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2207
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bgn
Name: biglycan
Acc ID: CHEBI:94287
Term: erastin
Definition: A member of the class of quinazolines that is quinazolin-4(3H)-one in which the hydrogens at positions 2 and 3 are replaced by 1-{4-[(4-chlorophenoxy)acetyl]piperazin-1-yl}ethyl and 2-ethoxyphenyl groups, respectively. It is an inhibitor of voltage-dependent anion-selective channels (VDAC2 and VDAC3) and a potent ferroptosis inducer.
Chemical ID: MESH:C477224
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bgndecreases expressionISOBGN (Homo sapiens)6480464CTDerastin results in decreased expression of BGN mRNA alternative formPMID:35234341
Bgnmultiple interactionsISOBGN (Homo sapiens)6480464CTDBGN mRNA alternative form inhibits the reaction [erastin results in decreased expression of MKI67 protein]; erastin inhibits the reaction [[Antineoplastic Agents, Immunological results in decreased susceptibility to Antineoplastic Agents, Immunological] which results in increased expression of BGN mRNA alternative form]PMID:35234341
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