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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2200
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2l1
Name: Bcl2-like 1
Acc ID: CHEBI:2687
Term: amsacrine
Definition: A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
Chemical ID: MESH:D000677
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2l1decreases expressionISOBCL2L1 (Homo sapiens)6480464CTDAmsacrine results in decreased expression of BCL2L1 proteinPMID:37451322
Bcl2l1multiple interactionsISOBCL2L1 (Homo sapiens)6480464CTD[[Amsacrine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of ELAVL1 mRNA] which results in increased degradation of BCL2L1 mRNA; [[Amsacrine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of ELAVL1 mRNA] which results in increased degradation of BCL2L1 mRNA; ELAVL1 protein inhibits the reaction [Amsacrine results in decreased expression of BCL2L1 mRNA]; ELAVL1 protein inhibits the reaction [Amsacrine results in increased degradation of BCL2L1 mRNA]PMID:37451322
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