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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:3941
Term: cucurbitacin B
Definition: A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23; a hydroxy function at C-25 is acetylated.
Chemical ID: MESH:C041246
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDcucurbitacin B results in decreased expression of BCL2 mRNA; cucurbitacin B results in decreased expression of BCL2 proteinPMID:26183715
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTDcucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased expression of BCL2 mRNA]PMID:29250925
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[cucurbitacin B co-treated with Gefitinib] results in decreased expression of BCL2 mRNA; [cucurbitacin B co-treated with Gefitinib] results in decreased expression of BCL2 proteinPMID:26183715
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