Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:10022
Term: deoxynivalenol
Definition: A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.
Chemical ID: MESH:C007262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDdeoxynivalenol results in decreased expression of BCL2 mRNA; deoxynivalenol results in decreased expression of BCL2 proteinPMID:35817260
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDdeoxynivalenol results in decreased expression of BCL2 mRNA; deoxynivalenol results in decreased expression of BCL2 proteinPMID:17166419 PMID:22269384 PMID:37705238
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDdeoxynivalenol results in increased expression of BCL2 mRNAPMID:22269384
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTDCurcumin inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]; deoxynivalenol promotes the reaction [Aflatoxin B1 results in decreased expression of BCL2 mRNA]PMID:25445755 PMID:35817260
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTDAscorbic Acid inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]PMID:17166419
Go Back to source page   Continue to Ontology report