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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2175
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atp2a3
Name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atp2a3affects methylationISOATP2A3 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of ATP2A3 intron; Benzo(a)pyrene affects the methylation of ATP2A3 polyA tailPMID:30157460
Atp2a3increases expressionISOAtp2a3 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of ATP2A3 mRNAPMID:22228805
Atp2a3increases methylationISOATP2A3 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of ATP2A3 3' UTR; Benzo(a)pyrene results in increased methylation of ATP2A3 promoterPMID:27901495
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