GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Atf3 | increases expression | ISO | Atf3 (Mus musculus) | 6480464 | CTD | shikonin results in increased expression of ATF3 protein | PMID:37268198 | Atf3 | increases expression | ISO | ATF3 (Homo sapiens) | 6480464 | CTD | shikonin results in increased expression of ATF3 mRNA; shikonin results in increased expression of ATF3 protein | PMID:37268198 | Atf3 | multiple interactions | ISO | Atf3 (Mus musculus) | 6480464 | CTD | shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of ATF3 mRNA] | PMID:25451590 | Atf3 | multiple interactions | ISO | ATF3 (Homo sapiens) | 6480464 | CTD | [shikonin results in increased acetylation of HDAC1 protein] which results in increased expression of ATF3 protein; ATF3 protein promotes the reaction [shikonin results in decreased expression of GPX4 protein]; ATF3 protein promotes the reaction [shikonin results in decreased expression of SLC7A11 protein]; MYC protein inhibits the reaction [shikonin results in increased expression of ATF3 mRNA]; MYC protein inhibits the reaction [shikonin results in increased expression of ATF3 protein]; shikonin promotes the reaction [HDAC1 protein binds to ATF3 promoter] | PMID:37268198 | | ||||||||||||||||||||||
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