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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2088
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldh3a1
Name: aldehyde dehydrogenase 3 family, member A1
Acc ID: CHEBI:32585
Term: 4-hydroxynon-2-enal
Definition: An enal consisting of non-2-ene having an oxo group at the 1-position and a hydroxy group at the 4-position.
Chemical ID: MESH:C027576
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh3a1affects metabolic processingEXP 6480464CTDALDH3A1 protein affects the metabolism of 4-hydroxy-2-nonenalPMID:11018474
Aldh3a1affects response to substanceISOALDH3A1 (Homo sapiens)6480464CTDALDH3A1 protein affects the susceptibility to 4-hydroxy-2-nonenalPMID:15905174
Aldh3a1decreases response to substanceISOALDH3A1 (Homo sapiens)6480464CTDALDH3A1 protein results in decreased susceptibility to 4-hydroxy-2-nonenalPMID:11306050
Aldh3a1increases metabolic processingISOAldh3a1 (Mus musculus)6480464CTDALDH3A1 protein results in increased metabolism of 4-hydroxy-2-nonenalPMID:21256123
Aldh3a1increases oxidationISOALDH3A1 (Homo sapiens)6480464CTDALDH3A1 protein results in increased oxidation of 4-hydroxy-2-nonenalPMID:22339434
Aldh3a1multiple interactionsISOAldh3a1 (Mus musculus)6480464CTD[APC protein mutant form results in increased expression of ALDH3A1 mRNA] which affects the metabolism of 4-hydroxy-2-nonenalPMID:21967605
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