GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Aldh3a1 | increases expression | ISO | ALDH3A1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA | PMID:14645679 PMID:16545412 PMID:20106945 PMID:21632981 PMID:21871943 PMID:22178795 PMID:22316170 PMID:22889811 PMID:25690898 PMID:30439556 PMID:31255691 PMID:32890658 | Aldh3a1 | increases expression | ISO | Aldh3a1 (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA | PMID:14625279 PMID:15034205 PMID:15894712 PMID:17682057 PMID:20713471 PMID:24374135 PMID:25908611 PMID:8148869 | Aldh3a1 | increases methylation | ISO | ALDH3A1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased methylation of ALDH3A1 5' UTR; Benzo(a)pyrene results in increased methylation of ALDH3A1 exon; Benzo(a)pyrene results in increased methylation of ALDH3A1 promoter | PMID:27901495 | Aldh3a1 | multiple interactions | ISO | ALDH3A1 (Homo sapiens) | 6480464 | CTD | cobaltous chloride inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]; Deferoxamine inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]; nickel chloride inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]; Oxygen deficiency inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA] | PMID:14645679 | Aldh3a1 | multiple interactions | ISO | Aldh3a1 (Mus musculus) | 6480464 | CTD | [arsenite co-treated with Benzo(a)pyrene] results in increased expression of ALDH3A1 mRNA; [Azacitidine co-treated with Butyrates] inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]]; [Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of ALDH3A1 mRNA; [Benzo(a)pyrene results in increased activity of AHR protein] which results in increased expression of ALDH3A1 mRNA; [Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]; Azacitidine inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]]; Benzo(a)pyrene promotes the reaction [AHR protein binds to ALDH3A1 promoter]; Benzo(a)pyrene promotes the reaction [sodium bichromate results in decreased expression of ALDH3A1 mRNA]; Butyrates inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]]; Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA] | PMID:14625279 PMID:15894712 PMID:17682057 PMID:19654925 PMID:22613061 PMID:32553695 | | ||||||||||||||||||||||
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