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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2087
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldh1a1
Name: aldehyde dehydrogenase 1 family, member A1
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh1a1increases expressionEXP 6480464CTDPhenobarbital results in increased expression of ALDH1A1 mRNAPMID:17381134 PMID:19162173 PMID:19695238 PMID:22584684 PMID:25182419 PMID:28520973
Aldh1a1decreases expressionISOAldh1a1 (Mus musculus)6480464CTDPhenobarbital results in decreased expression of ALDH1A1 proteinPMID:35881160
Aldh1a1increases expressionISOAldh1a1 (Mus musculus)6480464CTDPhenobarbital results in increased expression of ALDH1A1 mRNA; Phenobarbital results in increased expression of ALDH1A1 proteinPMID:17998271 PMID:28541575
Aldh1a1increases expressionISOALDH1A1 (Homo sapiens)6480464CTDPhenobarbital results in increased expression of ALDH1A1 proteinPMID:28541575 PMID:35881160
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