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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2074
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ahr
Name: aryl hydrocarbon receptor
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ahrdecreases activityISOAhr (Mus musculus)6480464CTDepigallocatechin gallate results in decreased activity of AHR proteinPMID:15794642
Ahrdecreases methylationISOAhr (Mus musculus)6480464CTDepigallocatechin gallate results in decreased methylation of AHR promoterPMID:34600025
Ahrincreases expressionISOAhr (Mus musculus)6480464CTDepigallocatechin gallate results in increased expression of AHR mRNA; epigallocatechin gallate results in increased expression of AHR proteinPMID:34600025
Ahrmultiple interactionsISOAhr (Mus musculus)6480464CTDepigallocatechin gallate binds to and results in decreased activity of AHR protein; epigallocatechin gallate inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; epigallocatechin gallate inhibits the reaction [Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein]; epigallocatechin gallate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]PMID:11853182 PMID:12870889 PMID:20450880
Ahrmultiple interactionsISOAHR (Homo sapiens)6480464CTDepigallocatechin gallate binds to and results in decreased activity of AHR protein; epigallocatechin gallate inhibits the reaction [[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; epigallocatechin gallate inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein]; epigallocatechin gallate inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein]PMID:11064004 PMID:20450880
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