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GENE - TERM ANNOTATION REPORT

RGD ID: 18915831
Species: Heterocephalus glaber
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator activated receptor gamma
Acc ID: DOID:13207
Term: proliferative diabetic retinopathy
Definition: This advanced, severe stage of diabetic retinopathy mainly occurs when many of the blood vessels in the retina close, preventing sufficient blood flow. In an attempt to supply blood to the area where the original vessels closed, the retina responds by growing new blood vessels, which is called neovascularization.
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PpargonsetISOPPARG (Homo sapiens)9068941RGD PMID:18541841 REF_RGD_ID:2301854
PpargsusceptibilityISOPPARG (Homo sapiens)9068941RGDassociated with Diabetes Mellitus, Type 2;DNA:snp:promoter:c.-2819A>G (human)PMID:19125195 REF_RGD_ID:8699508
PpargsusceptibilityISOPPARG (Homo sapiens)9068941RGDDNA:snp:cds:p.P12A (rs1801282) (human)PMID:23559865 REF_RGD_ID:8552820
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