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GENE - TERM ANNOTATION REPORT

RGD ID: 18761749
Species: Chlorocebus sabaeus
RGD Object: Gene
Symbol: LOC103243509
Name: neuroendocrine secretory protein 55
Acc ID: PW:0000227
Term: G protein mediated signaling pathway via Galphas family
Definition: Based on sequence similarity, the Galpha genes have been grouped into four classes. Exchange of GDP to GTP promoted through binding to receptors dissociates the heterotrimeric Galpa/beta/gamma complex. GTP-bound Galpha can then interact with downstream effectors. Lipid modification of Galpha regulates membrane localization and interactions with specific effectors.
Definition Source(s): PMID:12040175, PMID:15747061
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
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