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GENE - TERM ANNOTATION REPORT

RGD ID: 1606038
Species: Homo sapiens
RGD Object: Gene
Symbol: DNMT3A
Name: DNA methyltransferase 3 alpha
Acc ID: DOID:9119
Term: acute myeloid leukemia
Definition: A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells. (DO)
Definition Source(s): http://cancergenome.nih.gov/cancersselected/acutemyeloidleukemia "DO" "DO", http://en.wikipedia.org/wiki/Acute_myeloid_leukemia "DO" "DO", http://www.cancer.gov/dictionary?cdrid=44363 "DO" "DO", https://www.cancer.org/cancer/acute-myeloid-leukemia/detection-diagnosis-staging/how-classified.html "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DNMT3A IAGP 9589067RGDDNA:mutations:cds: 
DNMT3Adisease_progressionIAGP 11041123RGDDNA:missense mutation:exon:p.R882 (human) 
DNMT3AsusceptibilityIAGP 11041122RGDassociated with Myelodysplastic Syndromes; DNA:mutations:cds: 
DNMT3AtreatmentIAGP 11041120RGDDNA:mutation:: 
DNMT3Adisease_progressionIDA 11041121RGDDNA:hypomethylation: : 
DNMT3A IEP 9588667RGDmRNA:increased expression:CD34+ bone marrow cells 
DNMT3A IAGP 7240710OMIM  
DNMT3A EXP 11554173CTDCTD Direct Evidence: marker/mechanismPMID:27335278
DNMT3A IAGP (Homo sapiens) or (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemia | ClinVar Annotator: match by term: Leukemia, acute myeloid, somaticPMID:25741868 PMID:28492532
DNMT3A IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemia, adultPMID:21067377 PMID:21518476 PMID:22160010 PMID:22722925 PMID:22744846 PMID:22898539 PMID:24606448 PMID:24622842 PMID:24656771 PMID:25741868 PMID:26619011 PMID:26876596 PMID:27991732 PMID:28252636 PMID:28492532 PMID:28941052 PMID:30185810 PMID:31582562 PMID:31620784 PMID:31640986 PMID:31961069 PMID:32123902 PMID:32385248 PMID:34788385
DNMT3A IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemiaPMID:21067377 PMID:22160010 PMID:22898541 PMID:26619011
DNMT3A IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemiaPMID:21067377 PMID:21518476 PMID:22160010 PMID:22744846 PMID:22898539 PMID:24606448 PMID:24656771 PMID:25741868 PMID:26619011 PMID:26822784 PMID:27317772 PMID:28432085 PMID:28492532 PMID:28941052 PMID:29900417 PMID:30478443 PMID:31620784 PMID:31961069
DNMT3A IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemiaPMID:22160010 PMID:22898539
DNMT3A IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemiaPMID:21067377 PMID:21518476 PMID:22160010 PMID:22744846 PMID:22898540 PMID:25741868 PMID:27317772 PMID:28432085 PMID:28492532 PMID:34092059
DNMT3A IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemiaPMID:22160010 PMID:22898540
DNMT3A IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemiaPMID:24614070 PMID:25741868 PMID:28492532
DNMT3A IAGP (Homo sapiens) or (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemiaPMID:25741868
DNMT3A IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemiaPMID:25650308 PMID:25741868 PMID:28492532
DNMT3A IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemia 
DNMT3A IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemiaPMID:32581362
DNMT3A IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemiaPMID:25693834 PMID:25741868 PMID:34480172 PMID:34632574 PMID:36641501
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