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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1598133
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dram1
Name: DNA-damage regulated autophagy modulator 1
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dram1increases expressionISODRAM1 (Homo sapiens)6480464CTDFluorouracil results in increased expression of DRAM1 mRNAPMID:17982676
Dram1increases expressionISODram1 (Mus musculus)6480464CTDFluorouracil results in increased expression of DRAM1 proteinPMID:31288002
Dram1multiple interactionsISODRAM1 (Homo sapiens)6480464CTDTP53 protein promotes the reaction [Fluorouracil results in increased expression of DRAM1 mRNA]PMID:17982676
Dram1multiple interactionsISODram1 (Mus musculus)6480464CTDFluorouracil promotes the reaction [Luteolin results in increased expression of DRAM1 protein]; Luteolin promotes the reaction [Fluorouracil results in increased expression of DRAM1 protein]PMID:31288002
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