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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1592081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mpo
Name: myeloperoxidase
Acc ID: CHEBI:8249
Term: piroxicam
Definition: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide with the exocyclic nitrogen of 2-aminopyridine. A non-steroidal anti-inflammatory drug of the oxicam class, it is used to relieve pain and works by preventing the production of endogenous prostaglandins involved in the mediation of pain, stiffness, tenderness and swelling.
Chemical ID: MESH:D010894
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mpodecreases activityEXP 6480464CTDPiroxicam results in decreased activity of MPOPMID:11996850
Mpoincreases activityEXP 6480464CTDPiroxicam results in increased activity of MPO proteinPMID:15309881
Mpoincreases expressionEXP 6480464CTDPiroxicam results in increased expression of MPO proteinPMID:16080005
Mpomultiple interactionsEXP 6480464CTDpantoprazole inhibits the reaction [Piroxicam results in increased expression of MPO protein]PMID:16080005
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