GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mpo | decreases activity | EXP | | 6480464 | CTD | nimesulide results in decreased activity of MPO | PMID:11996850 | Mpo | multiple interactions | EXP | | 6480464 | CTD | nimesulide inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] | PMID:11137876 | Mpo | multiple interactions | ISO | MPO (Homo sapiens) | 6480464 | CTD | [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of nimesulide metabolite] which results in increased chemical synthesis of nimesulide metabolite; [[MPO protein co-treated with Hypochlorous Acid] results in increased oxidation of nimesulide metabolite] which results in increased chemical synthesis of nimesulide metabolite; [MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of and affects the activity of nimesulide metabolite; [MPO protein co-treated with Hypochlorous Acid] results in increased oxidation of and affects the activity of nimesulide metabolite | PMID:20939553 | | ||||||||||||||||||||||
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