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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1583689
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ugt1a5
Name: UDP glucuronosyltransferase family 1 member A5
Acc ID: CHEBI:45951
Term: trifluoperazine
Definition: A member of the class of phenothiazines that is phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.
Chemical ID: MESH:D014268
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a5increases activityISOUGT1A4 (Homo sapiens)6480464CTDTrifluoperazine results in increased activity of UGT1A4 proteinPMID:26875642
Ugt1a5increases glucuronidationISOUGT1A4 (Homo sapiens)6480464CTDUGT1A4 protein results in increased glucuronidation of TrifluoperazinePMID:15135306 PMID:15475412 PMID:25393417 PMID:25448279 PMID:33290829
Ugt1a5multiple interactionsISOUGT1A4 (Homo sapiens)6480464CTDFinasteride inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Trifluoperazine]; hecogenin inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Trifluoperazine]; licochalcone A inhibits the reaction [Trifluoperazine results in increased activity of UGT1A4 protein]; Trifluoperazine inhibits the reaction [UGT1A4 protein results in increased glucuronidation of afloqualone]PMID:15475412 PMID:25448279 PMID:26875642 PMID:33290829
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