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GENE - TERM ANNOTATION REPORT

RGD ID: 1564085
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lats1
Name: large tumor suppressor kinase 1
Acc ID: GO:0035329
Term: hippo signaling
Definition: An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation.
Definition Source(s): PMID:17318211, PMID:18328423, PMID:36347846
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lats1acts_upstream_of_or_withinISOLats1 (Mus musculus)1624291RGDMGI:103262 MGI:1927144 MGI:1929004 PMID:18369314

PMID:18369314
Lats1involved_inISOLATS1 (Homo sapiens)1624291RGD PMID:20412773 PMID:35429439

PMID:20412773 PMID:35429439
Lats1involved_inIBAFB:FBgn0011739 or MGI:1333883 or MGI:1354386 or PANTHER:PTN002390470 or UniProtKB:O95835 or UniProtKB:Q9NRM71600115GO_CentralGO_REF:0000033

GO_REF:0000033
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