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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1564085
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lats1
Name: large tumor suppressor kinase 1
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lats1multiple interactionsISOLATS1 (Homo sapiens)6480464CTD[Cadmium Chloride results in decreased activity of LATS1 protein] which results in decreased phosphorylation of MTF1 protein; [Cadmium Chloride results in decreased activity of LATS1 protein] which results in decreased phosphorylation of YAP1 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of LATS1 mRNA; Cadmium Chloride results in decreased activity of and results in decreased phosphorylation of LATS1 proteinPMID:35027733 PMID:35301059
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