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GENE - TERM ANNOTATION REPORT

RGD ID: 1558619
Species: Mus musculus
RGD Object: Gene
Symbol: Ctsb
Name: cathepsin B
Acc ID: DOID:10941
Term: intracranial aneurysm
Definition: Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE. (From Adams et al., Principles of Neurology, 6th ed, p841)
Definition Source(s): MESH:D002532
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctsb ISOCtsb (Rattus norvegicus)2306495RGDmRNA, protein:increased expression, increased activity:Circle of Willis (rat) 
Ctsb ISOCTSB (Homo sapiens)2306495RGDprotein:increased expression:cerebral aneurysm (human) 
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