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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1558619
Species: Mus musculus
RGD Object: Gene
Symbol: Ctsb
Name: cathepsin B
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctsbdecreases expressionEXP 6480464CTDIsoproterenol results in decreased expression of CTSB mRNAPMID:21335049
Ctsbdecreases activityISOCtsb (Rattus norvegicus)6480464CTDIsoproterenol results in decreased activity of CTSB proteinPMID:17188415
Ctsbincreases activityISOCtsb (Rattus norvegicus)6480464CTDIsoproterenol results in increased activity of CTSB proteinPMID:17188415 PMID:18294627 PMID:2015110 PMID:20391626 PMID:25560919 PMID:8534267
Ctsbmultiple interactionsISOCtsb (Rattus norvegicus)6480464CTDcaffeic acid inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]; Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]; epigallocatechin gallate inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]; naringin inhibits the reaction [Isoproterenol results in decreased activity of CTSB protein]; naringin inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]; Phytic Acid inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]PMID:17188415 PMID:18294627 PMID:20391626 PMID:25560919 PMID:8534267
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