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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1558619
Species: Mus musculus
RGD Object: Gene
Symbol: Ctsb
Name: cathepsin B
Acc ID: CHEBI:3638
Term: chloroquine
Definition: An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Chemical ID: MESH:D002738
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctsbmultiple interactionsEXP 6480464CTDChloroquine promotes the reaction [Arsenic results in increased activity of CTSB protein]PMID:36117518
Ctsbdecreases activityISOCTSB (Homo sapiens)6480464CTDChloroquine results in decreased activity of CTSB proteinPMID:30338810
Ctsbincreases expressionISOCtsb (Rattus norvegicus)6480464CTDChloroquine results in increased expression of CTSB proteinPMID:2759144
Ctsbmultiple interactionsISOCTSB (Homo sapiens)6480464CTD[Chloroquine co-treated with dactolisib] affects the localization of CTSB protein; [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of CTSB protein; Chloroquine inhibits the reaction [Arsenic Trioxide results in increased activity of CTSB protein]PMID:23151917 PMID:30338810 PMID:30821613
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