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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1558619
Species: Mus musculus
RGD Object: Gene
Symbol: Ctsb
Name: cathepsin B
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctsbincreases expressionEXP 6480464CTDDoxorubicin results in increased expression of CTSB mRNAPMID:19001878
Ctsbmultiple interactionsEXP 6480464CTDPARP1 protein promotes the reaction [Doxorubicin results in increased expression of CTSB mRNA]PMID:19001878
Ctsbaffects expressionISOCTSB (Homo sapiens)6480464CTDDoxorubicin affects the expression of CTSB mRNA; Doxorubicin affects the expression of CTSB proteinPMID:16705698 PMID:29385562
Ctsbdecreases expressionISOCTSB (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of CTSB mRNAPMID:29803840
Ctsbmultiple interactionsISOCTSB (Homo sapiens)6480464CTDCTSB protein results in increased cleavage of [Doxorubicin analog binds to ALB protein]PMID:17378599
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