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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1558600
Species: Mus musculus
RGD Object: Gene
Symbol: Ern1
Name: endoplasmic reticulum to nucleus signalling 1
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ern1multiple interactionsEXP 6480464CTD[Sirolimus co-treated with HRAS protein] results in decreased expression of ERN1 protein; PPARD protein affects the reaction [[Sirolimus co-treated with HRAS protein] results in decreased expression of ERN1 protein]PMID:24898257
Ern1multiple interactionsISOERN1 (Homo sapiens)6480464CTDSirolimus inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein]PMID:32283200
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