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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552917
Species: Mus musculus
RGD Object: Gene
Symbol: C6
Name: complement component 6
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
C6increases expressionEXP 6480464CTDperfluorooctanoic acid results in increased expression of C6 mRNAPMID:18467677
C6multiple interactionsEXP 6480464CTDPPARA protein inhibits the reaction [perfluorooctanoic acid results in increased expression of C6 mRNA]PMID:18467677
C6decreases expressionISOC6 (Homo sapiens)6480464CTDperfluorooctanoic acid results in decreased expression of C6 mRNAPMID:25868421
C6decreases expressionISOC6 (Rattus norvegicus)6480464CTDperfluorooctanoic acid results in decreased expression of C6 mRNAPMID:16221955
C6multiple interactionsISOC6 (Rattus norvegicus)6480464CTD[Zeranol co-treated with perfluorooctanoic acid] results in increased expression of C6 mRNAPMID:35163327
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