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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552855
Species: Mus musculus
RGD Object: Gene
Symbol: Hmga2
Name: high mobility group AT-hook 2
Acc ID: CHEBI:15866
Term: 2-deoxy-D-glucose
Definition: A deoxyglucose that is D-glucose in which the hydroxy group at position 2 has been replaced by a hydrogen. It is an antimetabolite of glucose with antiviral activity, which acts by inhibiting the glycosylation of glycoproteins and glycolipids. Used as an antiherpes agent.
Chemical ID: MESH:D003847
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmga2multiple interactionsISOHMGA2 (Homo sapiens)6480464CTDDeoxyglucose inhibits the reaction [HMGA2 protein results in decreased expression of COX4 protein]; Deoxyglucose inhibits the reaction [HMGA2 protein results in decreased expression of ND1 protein]; Deoxyglucose inhibits the reaction [HMGA2 protein results in increased expression of HK2 protein]; Deoxyglucose inhibits the reaction [HMGA2 protein results in increased expression of MMP2 protein]; Deoxyglucose inhibits the reaction [HMGA2 protein results in increased expression of MMP9 protein]PMID:34481905
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