GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Myd88 | affects localization | EXP | | 6480464 | CTD | Lipopolysaccharides affects the localization of MYD88 protein | PMID:37182445 | Myd88 | decreases expression | EXP | | 6480464 | CTD | Lipopolysaccharides results in decreased expression of MYD88 mRNA | PMID:25896969 | Myd88 | increases expression | EXP | | 6480464 | CTD | Lipopolysaccharides results in increased expression of MYD88; Lipopolysaccharides results in increased expression of MYD88 mRNA; Lipopolysaccharides results in increased expression of MYD88 protein | PMID:15593098 PMID:18306459 PMID:20023007 PMID:20972769 PMID:21108626 PMID:22687549 PMID:24056979 PMID:24177262 PMID:25342887 PMID:25500681 PMID:26540118 PMID:26620692 PMID:28096963 PMID:31299241 PMID:31350693 PMID:31654708 PMID:32687258 PMID:33285210 PMID:34029560 | Myd88 | multiple interactions | EXP | | 6480464 | CTD | [4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile co-treated with Lipopolysaccharides] results in increased expression of MYD88 protein; [CRT 0066101 co-treated with Lipopolysaccharides] results in decreased expression of MYD88 protein; alternaramide inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]; alternaramide inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]; apigenin-6,8-di-C-glycopyranoside inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]; APOA1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]; Carticaine inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]; cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]; cordycepin inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]; cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]; diallyl trisulfide inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]; dorsomorphin inhibits the reaction [[4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile co-treated with Lipopolysaccharides] results in increased expression of MYD88 protein]; ethyl N-allyl-N-(2-methyl-3-(4-(4-amidinophenoxycarbonyl)phenyl)propenoyl)aminoacetate methanesulfonate inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]; Folic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88]; genipin inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]; kukoamine B inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]; Lipopolysaccharides results in decreased expression of and results in increased phosphorylation of MYD88 protein; methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]; MYD88 affects the reaction [Lipopolysaccharides affects the localization of and results in increased activity of GATA2 protein]; MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of BCL2 mRNA]; MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of BCL2L1 mRNA]; MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of BCL2L1 protein]; MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased secretion of IL13 protein]; MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased secretion of IL6 protein]; MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased secretion of TNF protein]; MYD88 protein affects the reaction [Lipopolysaccharides results in increased expression of SLC30A4 protein]; MYD88 protein affects the reaction [Lipopolysaccharides results in increased expression of SLC30A6 protein]; Quercetin inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in increased phosphorylation of MYD88 protein]; salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]; scolymoside inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]; timosaponin B-II inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein] | PMID:16892068 PMID:18306459 PMID:20023007 PMID:20972769 PMID:21108626 PMID:22687549 PMID:23735482 PMID:23940812 PMID:24056979 PMID:24177262 PMID:24453940 PMID:25342887 PMID:25500681 PMID:26540118 PMID:26620692 PMID:28096963 PMID:31350693 PMID:31654708 PMID:32687258 PMID:33285210 PMID:34029560 PMID:37182445 | Myd88 | increases expression | ISO | MYD88 (Homo sapiens) | 6480464 | CTD | Lipopolysaccharides results in increased expression of MYD88 mRNA; Lipopolysaccharides results in increased expression of MYD88 protein | PMID:20972769 PMID:32017913 PMID:32612008 PMID:34655103 PMID:35608548 PMID:36055550 PMID:36350155 | Myd88 | increases response to substance | ISO | Myd88 (Rattus norvegicus) | 6480464 | CTD | MYD88 protein results in increased susceptibility to Lipopolysaccharides | PMID:20865294 | Myd88 | multiple interactions | ISO | MYD88 (Homo sapiens) | 6480464 | CTD | 3-hydro-2,2,5,6-tetramethylpyrazine inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]; [CRT 0066101 co-treated with Lipopolysaccharides] results in decreased expression of MYD88 protein; [IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MYD88 protein; Acetylcysteine inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]]; Acetylcysteine inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of MYD88 protein]]; Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]; Apigenin analog inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]]; Apigenin analog inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of MYD88 protein]]; Apigenin inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]]; Apigenin inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of MYD88 protein]]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]; APOA1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]; Cholesterol, HDL inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]; euxanthone inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]; Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of MYD88 protein]; MYD88 affects the reaction [Lipopolysaccharides results in increased expression of MIR146A mRNA]; MYD88 protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAP2K4 protein]; SMIM20 protein modified form inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]; SMIM20 protein modified form inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]; ST2825 inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]]; ST2825 inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of MYD88 protein]]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]]; TLR4 protein promotes the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MYD88 protein] | PMID:20972769 PMID:21112663 PMID:24863965 PMID:32017913 PMID:32612008 PMID:34655103 PMID:34673087 PMID:36055550 PMID:36350155 PMID:37182445 | Myd88 | multiple interactions | ISO | Myd88 (Rattus norvegicus) | 6480464 | CTD | [Lipopolysaccharides co-treated with Titanium] results in decreased expression of MYD88 mRNA | PMID:21308757 | | ||||||||||||||||||||||
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