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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1549771
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ugt1a9
Name: UDP glucuronosyltransferase family 1 member A9
Acc ID: CHEBI:168396
Term: mycophenolic acid
Definition: A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.
Chemical ID: MESH:D009173
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a9affects metabolic processingISOUGT1A9 (Homo sapiens)6480464CTDUGT1A9 gene SNP affects the metabolism of Mycophenolic AcidPMID:18498916
Ugt1a9increases glucuronidationISOUGT1A9 (Homo sapiens)6480464CTDUGT1A9 protein results in increased glucuronidation of Mycophenolic AcidPMID:18816295 PMID:31742356
Ugt1a9multiple interactionsISOUGT1A9 (Homo sapiens)6480464CTD4-cresol inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide]; [4-cresol inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide]] which results in increased abundance of Mycophenolic Acid; [UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronidePMID:31742356
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