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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359715
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc13a4
Name: solute carrier family 13 member 4
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc13a4affects methylationISOSLC13A4 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of SLC13A4 promoterPMID:27901495
Slc13a4increases methylationISOSLC13A4 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of SLC13A4 5' UTR; Benzo(a)pyrene results in increased methylation of SLC13A4 exonPMID:27901495
Slc13a4increases mutagenesisISOSLC13A4 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased mutagenesis of SLC13A4 genePMID:25435355
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