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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359607
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Spi1
Name: Spi-1 proto-oncogene
Acc ID: CHEBI:183083
Term: indirubin
Definition: A member of the class of indolones that is 1,3-dihydro-2H-indol-2-one substituted by a 3-oxo-1,3-dihydro-2H-indol-2-ylidene group at position 3. It is the active component of Dang Gui Long Hui Wan, which has been used in traditional Chinese medicine to treat inflammatory diseases and chronic myeloid leukemia.
Chemical ID: MESH:C027185
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Spi1increases activityISOSPI1 (Homo sapiens)6480464CTDindirubin results in increased activity of SPI1 proteinPMID:16115123
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