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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359461
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dagla
Name: diacylglycerol lipase, alpha
Acc ID: CHEBI:191854
Term: arachidonyl-2'-chloroethylamide
Definition: A fatty amide obtained by the formal condensation of arachidonic acid with 2-chloroethanamine. It is a potent agonist of the CB1 receptor (Ki = 1.4 nM) and also has a low affinity for the CB2 receptor (Ki = 3100 nM).
Chemical ID: MESH:C119325
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Daglaincreases expressionISODAGLA (Homo sapiens)6480464CTDarachidonyl-2-chloroethylamide results in increased expression of DAGLA mRNAPMID:31912162
Daglaincreases expressionISODagla (Mus musculus)6480464CTDarachidonyl-2-chloroethylamide results in increased expression of DAGLA mRNA; arachidonyl-2-chloroethylamide results in increased expression of DAGLA proteinPMID:31912162
Daglamultiple interactionsISODAGLA (Homo sapiens)6480464CTDESRRG protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of DAGLA mRNA]; GSK5182 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of DAGLA mRNA]PMID:31912162
Daglamultiple interactionsISODagla (Mus musculus)6480464CTDarachidonyl-2-chloroethylamide promotes the reaction [ESRRG protein binds to DAGLA promoter]; ESRRG protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of DAGLA mRNA]; ESRRG protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of DAGLA protein]; ESRRG protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of DAGLA]; GSK5182 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of DAGLA mRNA]PMID:31912162
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