Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359220
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Klf2
Name: KLF transcription factor 2
Acc ID: CHEBI:48390
Term: cinacalcet
Definition: A secondary amino compound that is (1R)-1-(naphthalen-1-yl)ethanamine in which one of the hydrogens attached to the nitrogen is substituted by a 3-[3-(trifluoromethyl)phenyl]propyl group.
Chemical ID: MESH:D000069449
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Klf2decreases ubiquitinationISOKlf2 (Mus musculus)6480464CTDCinacalcet results in decreased ubiquitination of KLF2 proteinPMID:35635602
Klf2increases expressionISOKlf2 (Mus musculus)6480464CTDCinacalcet results in increased expression of KLF2 proteinPMID:35635602
Klf2multiple interactionsISOKlf2 (Mus musculus)6480464CTD[Cinacalcet inhibits the reaction [Adenine results in increased expression of TRAF2 protein]] which results in decreased ubiquitination of and results in decreased degradation of KLF2 protein; [Cinacalcet results in decreased expression of TRAF2 protein] which results in decreased ubiquitination of KLF2 protein; Cinacalcet inhibits the reaction [Adenine results in decreased expression of KLF2 protein]; TRAF2 protein inhibits the reaction [Cinacalcet results in increased expression of KLF2 protein]PMID:35635602
Go Back to source page   Continue to Ontology report