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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346751
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2B6
Name: cytochrome P450 family 2 subfamily B member 6
Acc ID: CHEBI:50867
Term: ciprofibrate
Definition: A cyclopropane that has formula C13H14Cl2O3.
Chemical ID: MESH:C019304
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2B6decreases expressionISOCyp2b10 (Mus musculus)6480464CTDciprofibrate results in decreased expression of CYP2B10 mRNAPMID:27225895
CYP2B6multiple interactionsISOCyp2b10 (Mus musculus)6480464CTDciprofibrate inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NR1I3 protein binds to CYP2B10 promoter]]; ciprofibrate inhibits the reaction [Phenobarbital results in increased expression of CYP2B10 mRNA]PMID:17962186
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