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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346751
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2B6
Name: cytochrome P450 family 2 subfamily B member 6
Acc ID: CHEBI:34757
Term: fenitrothion
Definition: An organic thiophosphate that is O,O-dimethyl O-phenyl phosphorothioate substituted by a methyl group at position 3 and a nitro group at position 4.
Chemical ID: MESH:D005278
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2B6decreases activityEXP 6480464CTDFenitrothion results in decreased activity of CYP2B6 proteinPMID:20183062 PMID:22310298 PMID:22634058
CYP2B6increases expressionEXP 6480464CTDFenitrothion results in increased expression of CYP2B6 mRNAPMID:22310298
CYP2B6multiple interactionsEXP 6480464CTDFenitrothion inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]PMID:22634058
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