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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346751
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2B6
Name: cytochrome P450 family 2 subfamily B member 6
Acc ID: CHEBI:119486
Term: efavirenz
Definition: 1,4-Dihydro-2H-3,1-benzoxazin-2-one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups (S configuration) and at the 6 position by chlorine. A non-nucleoside reverse transcriptase inhibitor with activity against HIV, it is used with other antiretrovirals for combination therapy of HIV infection.
Chemical ID: MESH:C098320
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2B6affects metabolic processingEXP 6480464CTDCYP2B6 gene polymorphism affects the metabolism of efavirenz; CYP2B6 protein affects the metabolism of efavirenzPMID:15622315 PMID:17559344
CYP2B6decreases activityEXP 6480464CTDefavirenz results in decreased activity of CYP2B6 proteinPMID:26599973
CYP2B6increases metabolic processingEXP 6480464CTDCYP2B6 protein results in increased metabolism of efavirenzPMID:15769884 PMID:17559344
CYP2B6multiple interactionsEXP 6480464CTD[efavirenz results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion; [efavirenz results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; [efavirenz results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNAPMID:17041008 PMID:26599973
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