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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345848
Species: Homo sapiens
RGD Object: Gene
Symbol: MMP3
Name: matrix metallopeptidase 3
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MMP3decreases expressionEXP 6480464CTDHydrogen Peroxide results in decreased expression of MMP3 mRNAPMID:32949572
MMP3increases expressionEXP 6480464CTDHydrogen Peroxide results in increased expression of MMP3 mRNA; Hydrogen Peroxide results in increased expression of MMP3 proteinPMID:30231594 PMID:32949572 PMID:33522089
MMP3multiple interactionsEXP 6480464CTDloliolide inhibits the reaction [Hydrogen Peroxide results in increased expression of MMP3 mRNA]; SNAI2 protein affects the reaction [Hydrogen Peroxide results in increased expression of MMP3 protein]; SNAI2 protein inhibits the reaction [SNHG3 mRNA affects the reaction [Hydrogen Peroxide results in increased expression of MMP3 protein]]; SNHG3 mRNA affects the reaction [Hydrogen Peroxide results in increased expression of MMP3 protein]PMID:30231594 PMID:33522089
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