GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | TNF | increases secretion | EXP | | 6480464 | CTD | Heme analog results in increased secretion of TNF protein | PMID:23355332 | TNF | multiple interactions | EXP | | 6480464 | CTD | Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]] | PMID:11076874 | TNF | increases expression | ISO | Tnf (Mus musculus) | 6480464 | CTD | Heme results in increased expression of TNF mRNA; Heme results in increased expression of TNF protein | PMID:36115635 | TNF | multiple interactions | ISO | Tnf (Mus musculus) | 6480464 | CTD | LY96 protein promotes the reaction [Heme results in increased expression of TNF mRNA]; LY96 protein promotes the reaction [Heme results in increased expression of TNF protein] | PMID:36115635 | | ||||||||||||||||||||||
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