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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1331948
Species: Mus musculus
RGD Object: Gene
Symbol: Gpbar1
Name: G protein-coupled bile acid receptor 1
Acc ID: CHEBI:16325
Term: lithocholic acid
Definition: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
Chemical ID: MESH:D008095
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpbar1increases response to substanceEXP 6480464CTDGPBAR1 protein results in increased susceptibility to Lithocholic AcidPMID:23041323
Gpbar1multiple interactionsEXP 6480464CTDLithocholic Acid binds to and results in increased activity of GPBAR1 proteinPMID:21454404 PMID:23041323
Gpbar1affects bindingISOGPBAR1 (Homo sapiens)6480464CTDLithocholic Acid binds to GPBAR1 proteinPMID:23566200
Gpbar1increases expressionISOGPBAR1 (Homo sapiens)6480464CTDLithocholic Acid results in increased expression of GPBAR1 mRNAPMID:25055961
Gpbar1multiple interactionsISOGPBAR1 (Homo sapiens)6480464CTD[Lithocholic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased abundance of Cyclic AMP; Lithocholic Acid analog binds to and results in increased activity of GPBAR1 protein; Lithocholic Acid binds to and results in increased activity of GPBAR1 proteinPMID:17963371 PMID:18180267 PMID:20023205
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