GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nlrp3 | increases expression | ISO | NLRP3 (Homo sapiens) | 6480464 | CTD | Cobalt results in increased expression of NLRP3 protein | PMID:32805375 | Nlrp3 | multiple interactions | ISO | NLRP3 (Homo sapiens) | 6480464 | CTD | [tungsten carbide co-treated with Cobalt] results in increased expression of NLRP3 mRNA; NLRP3 protein promotes the reaction [Cobalt results in increased expression of CASP1 protein modified form]; NLRP3 protein promotes the reaction [Cobalt results in increased expression of IL1B protein modified form]; NLRP3 protein promotes the reaction [Cobalt results in increased secretion of IL18 protein]; NLRP3 protein promotes the reaction [Cobalt results in increased secretion of IL1B protein] | PMID:18078969 PMID:32805375 | | ||||||||||||||||||||||
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