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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318014
Species: Homo sapiens
RGD Object: Gene
Symbol: NLRP3
Name: NLR family pyrin domain containing 3
Acc ID: CHEBI:64294
Term: 7-ketocholesterol
Definition: A cholestanoid that consists of cholesterol bearing an oxo substituent at position 7.
Chemical ID: MESH:C003001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NLRP3affects localizationISONlrp3 (Mus musculus)6480464CTD7-ketocholesterol affects the localization of NLRP3 proteinPMID:28633109
NLRP3multiple interactionsISONlrp3 (Mus musculus)6480464CTDAmitriptyline inhibits the reaction [7-ketocholesterol affects the localization of NLRP3 protein]PMID:28633109
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