GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Akr1b10 | multiple interactions | EXP | | 6480464 | CTD | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of AKR1B10 mRNA | PMID:19710929 | Akr1b10 | decreases activity | ISO | AKR1B10 (Homo sapiens) | 6480464 | CTD | pirinixic acid results in decreased activity of AKR1B10 protein; pirinixic acid results in decreased activity of AKR1B10 protein mutant form | PMID:18325492 | Akr1b10 | increases expression | ISO | AKR1B10 (Homo sapiens) | 6480464 | CTD | pirinixic acid results in increased expression of AKR1B10 mRNA | PMID:26198647 | Akr1b10 | multiple interactions | ISO | AKR1B10 (Homo sapiens) | 6480464 | CTD | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of AKR1B10 mRNA; pirinixic acid inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; pirinixic acid inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde] | PMID:19028477 PMID:19710929 | | ||||||||||||||||||||||
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