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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315314
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP46A1
Name: cytochrome P450 family 46 subfamily A member 1
Acc ID: CHEBI:34310
Term: (24S)-24-hydroxycholesterol
Definition: A 24-hydroxycholesterol that has S configuration at position 24. It is the major metabolic breakdown product of cholesterol in the brain.
Chemical ID: MESH:C044563
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP46A1affects abundanceEXP 6480464CTDCYP46A1 gene SNP affects the abundance of 24-hydroxycholesterolPMID:19286353
CYP46A1increases chemical synthesisEXP 6480464CTDCYP46A1 protein results in increased chemical synthesis of 24-hydroxycholesterolPMID:14640697
CYP46A1increases metabolic processingEXP 6480464CTDCYP46A1 protein results in increased metabolism of 24-hydroxycholesterolPMID:14640697
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