Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313526
Species: Mus musculus
RGD Object: Gene
Symbol: Mki67
Name: antigen identified by monoclonal antibody Ki 67
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mki67increases expressionEXP 6480464CTDDiethylnitrosamine results in increased expression of MKI67 mRNA; Diethylnitrosamine results in increased expression of MKI67 proteinPMID:17854601 PMID:17942915
Mki67multiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of MKI67 mRNA; MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of MKI67 protein]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MKI67 mRNA]PMID:17854601 PMID:17942915 PMID:24535843
Mki67increases expressionISOMki67 (Rattus norvegicus)6480464CTDDiethylnitrosamine results in increased expression of MKI67 proteinPMID:24012840 PMID:37527026
Mki67increases expressionISOMKI67 (Homo sapiens)6480464CTDDiethylnitrosamine results in increased expression of MKI67 proteinPMID:21776270
Mki67multiple interactionsISOMki67 (Rattus norvegicus)6480464CTD[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein; [Diethylnitrosamine co-treated with Cyclohexanols] results in increased expression of MKI67 protein; [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of MKI67 protein; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein]; Proliferating Cell Nuclear Antigen inhibits the reaction [Diethylnitrosamine results in increased expression of MKI67 protein]PMID:17393424 PMID:17651763 PMID:23665045 PMID:24012840
Go Back to source page   Continue to Ontology report