GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mki67 | decreases expression | EXP | | 6480464 | CTD | Copper deficiency results in decreased expression of MKI67 protein | PMID:24013775 | Mki67 | decreases expression | ISO | MKI67 (Homo sapiens) | 6480464 | CTD | Copper results in decreased expression of MKI67 protein | PMID:32004626 | Mki67 | increases expression | ISO | Mki67 (Rattus norvegicus) | 6480464 | CTD | Copper results in increased expression of MKI67 mRNA | PMID:30556269 | Mki67 | increases expression | ISO | MKI67 (Homo sapiens) | 6480464 | CTD | Copper results in increased expression of MKI67 protein | PMID:35809665 | Mki67 | multiple interactions | ISO | Mki67 (Rattus norvegicus) | 6480464 | CTD | Copper deficiency inhibits the reaction [[diisopropanolnitrosamine co-treated with Propylthiouracil] results in increased expression of MKI67 protein]; Copper inhibits the reaction [[diisopropanolnitrosamine co-treated with Propylthiouracil] results in increased expression of MKI67 protein] | PMID:19497425 | Mki67 | multiple interactions | ISO | MKI67 (Homo sapiens) | 6480464 | CTD | [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in increased expression of MKI67 protein; [NSC 689534 binds to Copper] which results in decreased expression of MKI67 mRNA; Copper promotes the reaction [[Progesterone co-treated with Estrogens] results in decreased expression of MKI67 protein] | PMID:20971185 PMID:32004626 PMID:35809665 | | ||||||||||||||||||||||
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