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GENE - TERM ANNOTATION REPORT

RGD ID: 1312024
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Irf8
Name: interferon regulatory factor 8
Acc ID: DOID:13241
Term: Behcet's disease
Definition: A vasculitis that is characterized by an autoimmune mediated inflammation of the blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Beh%C3%A7et%27s_disease "DO" "DO", http://www.nlm.nih.gov/medlineplus/behcetssyndrome.html "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Irf8 ISOIRF8 (Homo sapiens)329902079RGDDNA:Hypermethylation 
Irf8 ISOIRF8 (Homo sapiens)329955373RGDprotein:decreased expression:Peripheral blood mononuclear cells, monocytes (human) 
Irf8susceptibilityISOIRF8 (Homo sapiens)329902077RGDDNA:SNPs,haplotypes: (rs17445836, rs11642873) (human) 
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