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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311841
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akr1c2
Name: aldo-keto reductase family 1, member C2
Acc ID: CHEBI:31622
Term: flunitrazepam
Definition: A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.
Chemical ID: MESH:D005445
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1c2decreases activityISOAKR1C2 (Homo sapiens)6480464CTDFlunitrazepam results in decreased activity of AKR1C2 proteinPMID:11995921
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